Pre & Post-Coma VIDEOS ....  Click here







Dear Dr Kirkpatrick,


We would like to thank you in advance for evaluating and considering Kaci for the Ketamine Coma Study, which is taking place in Monterrey Mexico.



Kaci has had RSD since March 2005. Her pain originated in her right foot and has since spread to both feet from her ankles down.

Upon diagnosis of her RSD her Dr. was adamant that Kaci walk without the use of any aids. She has been diligent in attending physical therapy the last year and a half - undergoing countless hours of desensitization and excruciatingly painful exercises to maintain her mobility.

In efforts to control her pain she has been on numerous medications: antidepressants, anticonvulsants, anti-inflammatory drugs, and various narcotics. She has tried a three-day IV infusion of Pamidronate as well.

In the past seven months Kaci has had five continuous lumbar epidurals, four same day epidurals, four Bier blocks, and three sympathetic blocks. She has tried acupuncture, hypnosis and biofeedback -- all with no success. In addition, she has spent a total of 45 nights in the hospital for pain related crises.

She has undergone two spinal cord stimulator trials: One being a percutaneous trial of both antegrade and retrograde lead placement for three weeks and the most recent a week long trial with four paddle leads, both of which failed.

As I write this synopsis, Kaci is currently on her ninth day in the hospital on low dose IV ketamine for pain control. She has been unable to wean off the Ketamine without going into a full-blown pain crises.

Prior to her life with RSD, Kaci was a well-rounded young lady. She was an A student in school, a competitive gymnast practicing 18 hours per week, and enjoyed activities with friends from church and school. Her life since RSD has dramatically changed. Last year she missed half of her 8th grade school year due to pain and ongoing treatments. Kaci is now a freshman in high school and she has only been able to attend school 1 ½ out of the first 6 weeks due to recent hospitalizations. Needless to say she is not involved in any sports and

would be happy just to be able to walk/sit without pain. Other than RSD, Kaci is a healthy 15-year-old girl.

We have read the numerous articles about ketamine and the ketamine coma studies taking place since our research of RSD and treatment options began upon her diagnosis. Never thinking we would be at this point in her treatment we are now convinced that this may be her ticket to regaining her life back.

Both my husband and I have read and understand all the risks involved with such treatment and are ready to undergo what others might perceive as extreme measures in the hope of giving Kaci a second chance at life. I myself am particularly comfortable with the coma study as I am a nurse with past ICU experience and have cared for many patients placed in induced comas for various medical reasons. Kaci is willing and ready to do anything it takes to end the pain and regain her life back as well.

Our hope and prayer is that Kaci would be accepted into the study at this time as we feel we have thoroughly exhausted all other medical options and we are fearful of further progression of her RSD.

Again, we thank you for your time in meeting with us and evaluating her case.

With strong hope of finding a cure for this horrible disease,

Linda Corrigan
Littleton, Colorado


Mother of Kaci Corrigan


Editor's Note:

There is considerable debate over the relative merits of low dose ketamine infusions vs ketamine coma for CRPS.

15-year-old Kaci Corrigan provides us with a unique opportunity to gain insight into the efficacy of both procedures.  She underwent three separate low dose ketamine infusions prior to a 5-day ketamine coma procedure.

The low dose ketamine infusion was 7-16 mg per hour lasting for 5 to 10 days for each infusion. During the low dose ketamine infusions she experienced complete relief of her pain due to allodynia, which was associated with profound amnesia.

Kaci's allodynia was so severe that air currents generated by her dog wagging its tail triggered unbearable pain!

Unfortunately, each time the low dose infusions of ketamine were stopped, her pain due to allodynia returned immediately to the pre-infusion level.

Kaci’s mom, a critical care nurse, and the child felt the ketamine coma study was Kaci’s best (if not the only) option. Prior to the ketamine coma procedure, Kaci's symptoms became more severe and widespread despite aggressive medical management.  

Only after a 5-day coma with ketamine did Kaci sustain complete relief of her allodynia. See animated graph below demonstrating loss of allodynia.

Also, please find below a link to a 19-minute video documenting her experience 30 days after the ketamine coma procedure.

It is our policy to keep all research subjects advised of the outcomes (good and bad) from the ketamine coma study in real time by posting the results on a web page like this one.



Anthony F. Kirkpatrick, MD, PhD



Measurement of Pain Thresholds ....  Learn more



Video: 50-Minutes ~340K~ October 4, 2006

Kaci Corrigan: Pre-Coma Evaluation


Video: 19-Minutes ~340K~ August 8, 2007

Kaci Corrigan: Four Weeks Post-Coma


2-Year Post-Coma VIDEO  ... Click Here







Other Research Subjects




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